Advanced Oral Antibacterial/Anti-inflammatory Technology:
A Comprehensive Review of the Clinical Benefits of a Triclosan/Copolymer/Fluoride Dentifrice
Fotinos S. Panagakos, DMD, PhD Anthony R. Volpe, DDS, MS Margaret E. Petrone, JD
William DeVizio, DMD Robin M. Davies, BDS, PhD
Colgate-Palmolive Technology Center
Piscataway, NJ, USA
Howard M. Proskin, PhD
Howard M. Proskin and Associates
Rochester, NY, USA
• Introduction: Triclosan is a broad-spectrum antibacterial agent, marketed for use in oral products. It is effective against both grampositive and gram-negative bacteria. PVM/MA is the non-proprietary designation for a polyvinylmethyl ether maleic acid copolymer. It has been demonstrated that there is a greater uptake of triclosan to enamel and buccal epithelial cells from the use of a fluoride dentifrice containing triclosan and the PVM/MA copolymer than from a dentifrice containing triclosan alone. This Supplement details the results of antibacterial, anti-inflammatory, and short- and long-term plaque and gingivitis studies with a triclosan/copolymer/ fluoride dentifrice. Additionally, the Supplement reviews studies on the effect of a triclosan/copolymer/fluoride dentifrice on periodontitis, calculus, caries, whitening and stain removal, oral malodor, and on the microflora.
• Conclusion: Clinical studies indicate that the use of a triclosan/copolymer/fluoride dentifrice (Colgate® Total® Toothpaste) may provide oral health benefits beyond those associated with “traditional” toothpaste use, in a manner that is safe and effective. Studies presented in this Supplement demonstrate that Colgate Total Toothpaste provides superior protection against plaque and gingivitis, caries, oral malodor, exhibits superior stain removal, and provides protection against the progression of periodontal disease.
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